B12 & Homocysteine


B12 is reabsorbed or recycled within the body and this process is known as enterohepatic circulation, which is why it can take up to 25 years for a deficiency disease to develop. If your low B12 is due to absorption problems it could take only 3 years. Deficiency due to absorption problems could be due to:

  • Antibiotics
  • Alcohol (liver)
  • Smoking
  • Processed Food or Poor Diet
  • Stress
  • Elevated Blood Homocysteine
  • Aging (Over 50)
  • Those with gastric inflammation
  • Medications: Metformin, Omeprazole, Fluoroquinote, Oral Contraceptives

Enterohepatic Circulation

The good news is that by taking large frequent doses of B12 Methylcobalamin supplementation in a short time the enterohepatic system will restart.

Dr. Mc Cully Kilmer research on Homocysteine:

The Homocysteine Revolution

Elevated Blood Homocysteine causes:

  • Stroke/Heart Attack
  • Vascular Damage
  • Arteriosclerosis
  • Arterial Damage

High homocysteine is caused by too much methionine from protein and a deficiency of Vitamins B6, B12 and Folic Acid. Vegetarians are more protected because they consume less meat, fish and dairy products. High levels of animal based proteins puts a strain on the body for B6, B12 and Folic Acid. Plant based protein creates less strain. Also harsh chemical treatment of food processing i.e. milling wheat reduces B6 by 50% . Certain medications anticonvulsants (phenytoin) and antidiuretics also increase homocysteine = kidney failure.

Choose either optimal Diet or Supplements? If your levels are very low please supplement as directed by your GP until your levels are stable.

To increase levels of B12, B6 and Folic Acid levels via daily supplements:

  • B12 1,000 mcg sublingual
  • B6 10mg
  • Folic Acid 1.0mg

To increase levels naturally via diet:

  • Emphasize Fresh unprocessed Fruits and Vegetables
  • Whole grains and legumes
  • Reduce fats and sugars
  • 2-4 oz daily of either fresh meat, liver or eggs. (one egg is 2 ounces)

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